MACIR — Macrophage immunometabolism regulator
MACIR belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MACIR's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Monocyte-DC Differentiation Developmental | FBN2, FLT3, GASK1B, HAL, KLHL8, MAOA, MARCHF1, NFIA +1 more | View in SCUBA |
About the gene
| Synonyms | C5orf30, FLJ25291 |
|---|---|
| Chromosome | 5: 103258763-103278660 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cilium biogenesis/degradation, Inflammatory response, Protein transport, Transport |
Function
Regulates the macrophage function, by enhancing the resolution of inflammation and wound repair functions mediated by M2 macrophages. The regulation of macrophage function is, due at least in part, to its ability to inhibit glycolysis. May also play a role in trafficking of proteins via its interaction with UNC119 and UNC119B cargo adapters: may help the release of UNC119 and UNC119B cargo or the recycling of UNC119 and UNC119B. May play a role in ciliary membrane localization via its interaction with UNC119B and protein transport into photoreceptor cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.