FBN2 — Fibrillin 2
FBN2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FBN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Lamina Propria ECM ECM production | ADAMTS7, ADGRL4, ANGPTL6, BMP2, CBLN2, CYTL1, DHRS7C, FAM135B +14 more | View in SCUBA |
| Monocytes | Monocyte-DC Differentiation Developmental | FLT3, GASK1B, HAL, KLHL8, MACIR, MAOA, MARCHF1, NFIA +1 more | View in SCUBA |
| Smooth muscle cells | Microfibril ECM Assembly ECM remodeling | ADAM28, ITGA9, NEO1, NID1, PROM1, PSD3, SERPINE2, SPON1 +2 more | View in SCUBA |
About the gene
| Synonyms | CCA, DA9 |
|---|---|
| Chromosome | 5: 128257909-128659185 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Hormone |
Function
Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2- containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Hormone secreted by trophoblasts that promotes trophoblast invasiveness. Has glucogenic activity: is able to increase plasma glucose levels (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.