Monocyte-DC Differentiation
Gene co-expression module in Monocytes
| Category | Developmental |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
NFIA is a transcription factor critical for myeloid/DC differentiation; FLT3 marks dendritic cell precursors and is required for DC development; MARCHF1 (MARCH1) ubiquitinates MHC-II to downregulate antigen presentation, a hallmark of monocyte-to-DC transition; MACIR is a monocyte/macrophage-associated receptor; MAOA is expressed in tissue-resident macrophages. Together these genes suggest a monocyte differentiation state toward dendritic cell or tissue macrophage identity. Lower inflammation association than other modules in the batch.
Genes
FBN2, FLT3, GASK1B, HAL, KLHL8, MACIR, MAOA, MARCHF1, NFIA, RNASE4
Most correlated modules
- p38 MAPK Signaling · correlation 0.78
- Myeloid Activation · correlation 0.73
- Tissue-Resident Macrophage · correlation 0.69
- Leukotriene-Alarmin Response · correlation 0.63
- CCR2+ Monocyte Identity · correlation 0.62
- Glucocorticoid Response · correlation 0.56
- Pentose Phosphate Pathway · correlation 0.53
- Classical Monocyte Trafficking · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.