MAOA — Monoamine oxidase A
MAOA belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAOA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Quiescent Arterial EC Endothelial cell development | ABCG2, ANKRD50, CAMTA1, CDH23, CTNNAL1, CYB5A, HLF, INMT +10 more | View in SCUBA |
| Enterocytes | Carbohydrate Digestion/Detox Nutrient metabolism | CBR1, CMBL, DDC, GSTA1, HADHB, KBTBD11, PEBP1, SI +1 more | View in SCUBA |
| Goblet cells | Mature Colonocyte Function Epithelial development | ADD3, CERS6, CFTR, GAS6, LEFTY1, NOX1, PDCD4, PLBD1 +2 more | View in SCUBA |
| Monocytes | Monocyte-DC Differentiation Developmental | FBN2, FLT3, GASK1B, HAL, KLHL8, MACIR, MARCHF1, NFIA +1 more | View in SCUBA |
| Neutrophils | Immature Granulocyte Progenitor Developmental | ACSL4, AMPH, AVIL, CDC123, ENSG00000282804, HAL, HRH2, MPZL1 +3 more | |
| Smooth muscle cells | Stromal Chemokine Secretion Inflammation | C7, CCL19, CCL2, CCL21, CH25H, CXCL12, CXCL2, LINC00924 +9 more | View in SCUBA |
About the gene
| Chromosome | X: 43654907-43746817 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Oxidoreductase |
| Biological process | Catecholamine metabolism, Neurotransmitter degradation |
Function
Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.