MADCAM1 — Mucosal vascular addressin cell adhesion molecule 1
MADCAM1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MADCAM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venular Inflammatory Activation Inflammation | ACKR1, AIM2, ARL4C, ASAP3, BNC2, CFP, DUSP23, FAM3D +8 more | View in SCUBA |
About the gene
| Synonyms | MACAM1 |
|---|---|
| Chromosome | 19: 489176-505343 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Cell adhesion |
Function
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7- dependent adhesion strengthening, independent of L-selectin binding
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.