MAP4K3 — Mitogen-activated protein kinase kinase kinase kinase 3
MAP4K3 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MAP4K3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | MAPK Stress Kinase Inflammatory | ARHGAP26, BRAF, BTBD9, CRY1, CYTH3, EIF2AK3, ESYT2, EXT1 +12 more | View in SCUBA |
About the gene
| Synonyms | GLK, MAPKKKK3, RAB8IPL1 |
|---|---|
| Chromosome | 2: 39249266-39437301 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Function
Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.