MCOLN1 — Mucolipin TRP cation channel 1
MCOLN1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MCOLN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Golgi-Endosome Trafficking Vesicular traficking | ACSL4, ADPGK, ARRDC3, ATXN7L3B, CLN8, DDB1, DNAJC2, ETS2 +26 more | View in SCUBA |
| Monocytes | Tissue-destructive Macrophage Lysosomal & pahgocytosis | ACP5, ANKH, BCAT1, ENG, FABP5, ID3, IL10, KIFC3 +7 more | View in SCUBA |
About the gene
| Synonyms | ML4, MLIV, MST080, MSTP080, TRPM-L1, TRPML1 |
|---|---|
| Chromosome | 19: 7522624-7534009 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters, Voltage-gated ion channels |
| Molecular function | Ion channel |
| Biological process | Adaptive immunity, Calcium transport, Immunity, Ion transport, Transport |
Function
Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy. Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events. By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels. Seems to act as lysosomal active oxygen species (ROS) sensor involved in ROS-induced TFEB activation and autophagy. Also functions as a Fe(2+) permeable channel in late endosomes and lysosomes. Also permeable to Mg(2+), Na(+). K(+) and Cs(+) (By similarity). Proposed to play a role in zinc homeostasis probably implicating its association with TMEM163 In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). May contribute to cellular lipase activity within the late endosomal pathway or at the cell surface which may be involved in processes of membrane reshaping and vesiculation, especially the growth of tubular structures. However, it is not known, whether it conveys the enzymatic activity directly, or merely facilitates the activity of an associated phospholipase
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.