ETS2 — ETS proto-oncogene 2, transcription factor
ETS2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ETS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vasoactive GPCR Signaling Endothelial cell development | APLNR, BAIAP2L1, CALCRL, COPZ2, CYSLTR1, FAM110D, FAM167B, IFI16 +10 more | View in SCUBA |
| Enterocytes | Basal adhesion remodeling Migration & adhesion | EPB41L2, FNDC3B, HERC4, ITGA6, NT5C2, SESTD1, SGMS1, SH3RF1 +2 more | View in SCUBA |
| Fibroblasts | Inflammatory Fibroblast Activation Inflammatory | ATP2A2, BAMBI, C5AR2, CRISPLD2, CSNK1E, CTNNB1, DLC1, F2RL3 +11 more | View in SCUBA |
| Goblet cells | Stress Chromatin Remodeling chromatin regulation & transcription | GADD45A, KDM6B, PMAIP1, SDC4, SOX9, YBX3, ZBTB7A, ZFAND5 +1 more | View in SCUBA |
| Macrophages | Golgi-Endosome Trafficking Vesicular traficking | ACSL4, ADPGK, ARRDC3, ATXN7L3B, CLN8, DDB1, DNAJC2, EVI2A +26 more | View in SCUBA |
| Neutrophils | Neutrophil Adhesion Signaling Migration & adhesion | B3GNT5, GK, ICAM1, LCP2, PDE4B, SKIL, ZNF267 | |
| Pericytes | BMP-SMAD Signaling Developmental | CTSH, EXOC3L2, IL3RA, ITM2A, MCF2L, NDST1, PDE2A, SCARB1 +3 more | View in SCUBA |
About the gene
| Chromosome | 21: 38805183-38824955 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, RAS pathway related proteins, Transcription factors |
| Molecular function | DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.