Golgi-Endosome Trafficking
Gene co-expression module in Macrophages
| Category | Vesicular traficking |
|---|---|
| Genes | 35 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 35 genes have a known function matching the annotation |
Why this annotation
Hub genes include GGA1 (Golgi-localized gamma-ear-containing ARF-binding protein, Golgi-to-endosome vesicle trafficking), DDB1 (DNA damage binding protein/CRL4 ubiquitin ligase), FNIP1 (folliculin-interacting protein, mTORC1/lysosome), TRIM56 (E3 ubiquitin ligase), CLN8 (ER-to-Golgi cycling, neuronal ceroid lipofuscinosis gene), NECAP1 (clathrin-mediated endocytosis), STX6 (syntaxin 6, trans-Golgi/endosome SNARE), SCAMP4 (secretory carrier membrane protein), NUS1 (dolichol phosphate synthesis, ER/Golgi), ETS2 (myeloid TF), LTBR (lymphotoxin-beta receptor). The vesicular trafficking theme is strong: GGA1, CLN8, NECAP1, STX6, SCAMP4 all function in Golgi-endosome trafficking. EVI2A is a myeloid marker. This module reflects Golgi-endosomal vesicle trafficking in mono_mac.
Genes
ACSL4, ADPGK, ARRDC3, ATXN7L3B, CLN8, DDB1, DNAJC2, ETS2, EVI2A, EXOC7, FLCN, FNIP1, GGA1, GSK3A, HMGXB4, LTBR, MCOLN1, MFSD13A, MPZL1, NECAP1, NUS1, OGFRL1, PABPN1, POLR2J3-1, PYROXD1, SCAMP4, SGSH, STX6, TRIM56, TRIM8, UAP1L1, UNC45A, UPF3A, UPF3B, ZCCHC3
Most correlated modules
- Transcriptional Elongation · correlation 0.97
- Autophagy Lysosomal Regulation · correlation 0.94
- Endolysosomal Trafficking · correlation 0.94
- RNA Splicing Regulation · correlation 0.94
- RNA Processing Regulation · correlation 0.94
- Pre-mRNA Splicing · correlation 0.94
- Macrophage Endocytic Signaling · correlation 0.94
- RAS-MAPK Signaling · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.