ARRDC3 — Arrestin domain containing 3
ARRDC3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARRDC3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Immediate Early Response Stress | ATF3, CLK1, EIF4A2, EIF5, GADD45B, IER5, JUN, KLF6 +6 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Biogenesis Mitochondrial & OxPhos | ARFIP1, COG2, COQ7, DXO, EPM2AIP1, EPS8, HELQ, LETM2 +7 more | |
| Macrophages | Golgi-Endosome Trafficking Vesicular traficking | ACSL4, ADPGK, ATXN7L3B, CLN8, DDB1, DNAJC2, ETS2, EVI2A +26 more | View in SCUBA |
| Mucosal-associated invariant T cell | Apoptosis Regulation Immune regulation | ARF4, CARD8, CFLAR, CREBZF, MAPRE2, NABP1, PCF11, PPP1R10 +1 more |
About the gene
| Synonyms | KIAA1376, TLIMP |
|---|---|
| Chromosome | 5: 91368631-91383317 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transporters |
Function
Adapter protein that plays a role in regulating cell-surface expression of adrenergic receptors and probably also other G protein- coupled receptors. Plays a role in NEDD4-mediated ubiquitination and endocytosis af activated ADRB2 and subsequent ADRB2 degradation. May recruit NEDD4 to ADRB2. Alternatively, may function as adapter protein that does not play a major role in recruiting NEDD4 to ADRB2, but rather plays a role in a targeting ADRB2 to endosomes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.