ACSL4 — Acyl-CoA synthetase long chain family member 4
ACSL4 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ACSL4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Vesicular trafficking Housekeeping | ARL8B, BLOC1S2, C3orf38, DTX3L, EFCAB14, GGA2, HMGXB3, INPP4A +17 more | View in SCUBA |
| Endothelial | Inflammatory Lipid Metabolism Metabolite transfer | APOL1, CDK2AP2, COPS8, GBE1, GOLM1, MAPRE1, NPC1, PDLIM7 +5 more | View in SCUBA |
| Fibroblasts | Hypoxia Response Stress | AP2S1, ARFGAP3, C4orf48, EPAS1, HIF1A, IL4R, ISG20, NECTIN2 +8 more | View in SCUBA |
| Hematopoietic progenitor cells | Mast Cell Differentiation Granulocyte development | ALOX5AP, BACE2, CDK15, CNKSR3, FAM81B, FAM83F, FOXJ1, HDC +6 more | |
| Macrophages | Golgi-Endosome Trafficking Vesicular traficking | ADPGK, ARRDC3, ATXN7L3B, CLN8, DDB1, DNAJC2, ETS2, EVI2A +26 more | View in SCUBA |
| Neutrophils | Immature Granulocyte Progenitor Developmental | AMPH, AVIL, CDC123, ENSG00000282804, HAL, HRH2, MAOA, MPZL1 +3 more |
About the gene
| Synonyms | ACS4, FACL4, LACS4, MRX63, MRX68 |
|---|---|
| Chromosome | X: 109624244-109733403 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Ligase |
| Biological process | Fatty acid metabolism, Lipid metabolism |
Function
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose- stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.