MGAM — Maltase-glucoamylase
MGAM belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MGAM's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Brush-border nutrient uptake Absorption | ACE, CYBRD1, MS4A8, OAT, PDZK1, SLC23A1 | View in SCUBA |
| Monocytes | BPI Antibacterial Response Antibacterial | ADGRG3, ANXA3, BPI, CMTM2, CST7, CYP4F3, LGALS12, RGL4 +6 more | View in SCUBA |
| Neutrophils | Ubiquitin-Proteasome Turnover Housekeeping | BLTP3B, CACUL1, CLIP1, FBXL20, FBXO33, FGD3, IL18RAP, KIF13A +10 more |
About the gene
| Synonyms | MGA |
|---|---|
| Chromosome | 7: 141907813-142106747 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted membrane proteins |
| Molecular function | Glycosidase, Hydrolase, Multifunctional enzyme |
Function
Alpha-(1,4) exo-glucosidase involved in breakdown of dietary starch oligosaccharides in small intestine. Cleaves the non-reducing alpha-(1,4)-linked glucose residue in linear dextrins with retention of anomeric center stereochemistry. Mainly hydrolyzes short length oligomaltoses having two to seven glucose residues. Can cleave alpha-(1,2), alpha-(1,3) and alpha-(1,6) glycosidic linkages with lower efficiency, whereas beta glycosidic linkages are usually not hydrolyzed.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.