OAT — Ornithine aminotransferase
OAT belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OAT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Metabolic reprogramming Housekeeping | ATG16L2, ATP1A1, CCNYL1, CSKMT, EIF1AY, FAM241A, HMGCS1, ING1 +12 more | View in SCUBA |
| Enterocytes | Brush-border nutrient uptake Absorption | ACE, CYBRD1, MGAM, MS4A8, PDZK1, SLC23A1 | View in SCUBA |
| Macrophages | Early response genes Inflammatory | ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more | View in SCUBA |
| Mucosal-associated invariant T cell | NF-κB Survival Signaling Immune regulation | BIRC2, CWC25, GATA3, IL4I1, KPNA2, OTULIN, PIM2, RAB21 +4 more | |
| Smooth muscle cells | OXPHOS Complex I Mitochondrial & OxPhos | CLTB, COPS6, ETFB, IAH1, MRPS21, NDUFA2, NDUFB10, NDUFC2 +3 more | View in SCUBA |
About the gene
| Synonyms | HOGA |
|---|---|
| Chromosome | 10: 124397303-124418976 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Aminotransferase, Transferase |
Function
Catalyzes the reversible interconversion of L-ornithine and 2-oxoglutarate to L-glutamate semialdehyde and L-glutamate
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.