Brush-border nutrient uptake
Gene co-expression module in Enterocytes
| Category | Absorption |
|---|---|
| Genes | 7 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 7 of 7 genes have a known function matching the annotation |
Why this annotation
This is a brush-border absorptive program. It contains vitamin C transport (SLC23A1), the ferric reductase for iron uptake (CYBRD1), the transporter scaffold PDZK1, the disaccharidase MGAM, and ACE, with enterocyte markers MS4A8 and OAT. It is highly expressed mature enterocyte machinery.
Genes
ACE, CYBRD1, MGAM, MS4A8, OAT, PDZK1, SLC23A1
Most correlated modules
- Gluconeogenesis/fructose metabolism · correlation 0.95
- Colonocyte Solute Transport · correlation 0.95
- Chylomicron lipid absorption · correlation 0.93
- Villus-tip enterocyte transport · correlation 0.91
- Amino acid absorption · correlation 0.90
- Lipid/bile acid uptake · correlation 0.90
- Enterocyte lipid metabolism · correlation 0.89
- Brush-border Nutrient Uptake · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.