CYBRD1 — Cytochrome b reductase 1
CYBRD1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CYBRD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Brush-border nutrient uptake Absorption | ACE, MGAM, MS4A8, OAT, PDZK1, SLC23A1 | View in SCUBA |
| Fibroblasts | Microfibril ECM Fibroblast ECM production | CD302, CD81, COX7C, EPHX1, MFAP4, NFIX, NOP53, NUCKS1 +2 more | View in SCUBA |
| Macrophages | Innate Antiviral Sensing Innate immunity | ADA2, ADPRH, ALDH9A1, APOBEC3C, BST2, C2, CAT, CD4 +26 more | View in SCUBA |
| Smooth muscle cells | Adhesion Activation Migration & adhesion | ANXA2, ATP1B3, CAPNS1, CD44, FHL2, LAMC1, LGALS3, LGALS3BP +3 more | View in SCUBA |
About the gene
| Synonyms | CYB561A2, DCYTB, FLJ23462, FRRS3 |
|---|---|
| Chromosome | 2: 171522247-171558129 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted membrane proteins, Transporters |
| Molecular function | Oxidoreductase, Translocase |
| Biological process | Electron transport, Transport |
Function
Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes. It is also able to reduce extracellular monodehydro- L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood. May also act as a ferrireductase in airway epithelial cells (Probable). May also function as a cupric transmembrane reductase (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.