MMP16 — Matrix metallopeptidase 16
MMP16 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MMP16's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Inflammatory ECM Remodeling ECM remodeling | CNTNAP3B, CYB5RL, FOXO1, IL7, ITSN1, KIF3C, KRT8, LRCH2 +6 more | View in SCUBA |
About the gene
| Synonyms | C8orf57, DKFZp761D112, MT3-MMP |
|---|---|
| Chromosome | 8: 88032011-88328025 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Metalloprotease, Protease |
| Biological process | Collagen degradation |
Function
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.