Inflammatory ECM Remodeling
Gene co-expression module in Endothelial
| Category | ECM remodeling |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
Top hub genes include MMP16 (membrane-type matrix metalloproteinase critical for ECM remodeling and invasion), SRPX (sushi repeat-containing ECM protein), and PLA2R1 (phospholipase A2 receptor involved in lipid signaling and ECM interactions). IL7 and FOXO1 add inflammatory cytokine and endothelial transcription factor context. The module is strongly upregulated in both UC and CD inflammation and reverses in remission, consistent with active inflammatory ECM remodeling. SESN3 and ITSN1 contribute stress-response and endocytic signaling. KRT8 may reflect minor epithelial contamination but does not dominate the module. Compared to neighbor M75 (chemokine-driven inflammation) and M72 (signaling TFs), this module specifically captures the ECM remodeling arm of endothelial inflammatory response.
Genes
CNTNAP3B, CYB5RL, FOXO1, IL7, ITSN1, KIF3C, KRT8, LRCH2, MMP16, PLA2R1, SESN3, SRPX, STOX2, SULT1C4, TRMT9B
Most correlated modules
- Venous EC Identity · correlation 0.96
- Actomyosin Contractility · correlation 0.87
- NF-κB Stress Signaling · correlation 0.86
- Inflammatory Stress Response · correlation 0.81
- Hypoxia Stress Response · correlation 0.76
- Endothelial Chemokine Response · correlation 0.74
- Venous EC Identity · correlation 0.73
- Angiogenic Metabolic Adaptation · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.