IL7 — Interleukin 7
IL7 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | IL10/cytokine signaling Immune regulation | CASK, CCDC141, FOXN3, IL10RA, SLC12A6, STAMBPL1, TMEM154, TNFRSF13B +4 more | View in SCUBA |
| Endothelial | Inflammatory ECM Remodeling ECM remodeling | CNTNAP3B, CYB5RL, FOXO1, ITSN1, KIF3C, KRT8, LRCH2, MMP16 +6 more | View in SCUBA |
| Fibroblasts | Stromal Niche Signaling Developmental | ARHGAP20, COL15A1, CPNE8, ITIH5, KCNS3, KITLG, LIFR, PCDH19 +7 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic EC Identity Gut residence | CD36, CERS6, CHST15, DOCK5, EPS15, FRMD4B, FRY, ITSN1 +4 more | View in SCUBA |
About the gene
| Synonyms | IL-7 |
|---|---|
| Chromosome | 8: 78675743-78805523 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Cytokine, Growth factor |
Function
Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B- cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis. Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG. Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.