MOSMO — Modulator of smoothened
MOSMO belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MOSMO's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Vesicle Trafficking Signaling Housekeeping | ANK1, ANKRA2, B3GALNT2, C1orf216, C22orf39, CASC3, CCDC71L, CD80 +21 more | View in SCUBA |
About the gene
| Synonyms | ATTHOG, BC030336, C16orf52 |
|---|---|
| Chromosome | 16: 22007638-22087534 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Biological process | Differentiation |
Function
Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane. Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.