Vesicle Trafficking Signaling
Gene co-expression module in CD4⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 30 |
| Annotation certainty | 1 of 5 |
| Annotation consistency | 5 of 30 genes have a known function matching the annotation |
Why this annotation
Largely a diffuse low-expression module with some immune-relevant hubs: RASGRP4 (RAS guanyl-releasing protein, signaling), CD80 (costimulatory ligand), PAWR, CRKL (adaptor). However most genes are generic cellular machinery (CASC3, UBXN7, SCAMP3, CDC27, SLC38A10). Strong inflammation association. No dominant single program; the costimulatory/signaling genes plus generic membership suggest a broad activation-associated housekeeping module. Given uniform expression and mix, leaning toward a generic intracellular signaling/trafficking program.
Genes
ANK1, ANKRA2, B3GALNT2, C1orf216, C22orf39, CASC3, CCDC71L, CD80, CDC27, COPS8, CPNE3, CRKL, CTTNBP2NL, FLYWCH2, GRAMD2B, MOSMO, NDUFS1, PAFAH1B2, PAM, PAWR, PPME1, RASGRP4, SCAMP3, SLC38A10, SPG21, SYNE3, TCAF2, TIMM17B, UBXN7, ZBED4
Most correlated modules
- CD4 Lineage Identity · correlation 0.98
- Mitochondrial Translation · correlation 0.92
- Leukocyte Motility · correlation 0.90
- Lipid Metabolism · correlation 0.89
- Membrane Trafficking · correlation 0.84
- T Cell Signaling · correlation 0.83
- Immune Regulation · correlation 0.80
- mRNA Processing · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.