ANK1 — Ankyrin 1
ANK1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANK1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Vesicle Trafficking Signaling Housekeeping | ANKRA2, B3GALNT2, C1orf216, C22orf39, CASC3, CCDC71L, CD80, CDC27 +21 more | View in SCUBA |
| Hematopoietic progenitor cells | Mature Erythrocyte Erythropoietic | AHSP, APOC1, CA1, CD36, CD40LG, CDH1, FAM178B, HBB +4 more |
About the gene
| Synonyms | ANK, SPH1 |
|---|---|
| Chromosome | 8: 41653220-41896741 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
Function
Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.