CD80 — CD80 molecule
CD80 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD80's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Vesicle Trafficking Signaling Housekeeping | ANK1, ANKRA2, B3GALNT2, C1orf216, C22orf39, CASC3, CCDC71L, CDC27 +21 more | View in SCUBA |
| Monocytes | Tolerogenic Monocyte Activation Inflammatory | CCR5, CD40, GGT5, IDO1, IL4I1, MANF, PLA2G7, SLAMF7 +1 more | View in SCUBA |
About the gene
| Synonyms | B7-1, B7.1, CD28LG, CD28LG1 |
|---|---|
| Chromosome | 3: 119524293-119559614 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Host cell receptor for virus entry, Receptor |
| Biological process | Host-virus interaction |
Function
Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation. Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells together with the CD28 receptor which is constitutively expressed on the cell surface of T-cells. In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines. In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway. Also acts as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses. Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses (By similarity). (Microbial infection) Acts as a receptor for adenovirus subgroup B
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.