NFX1 — Nuclear transcription factor, X-box binding 1
NFX1 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NFX1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Immune Negative Regulation Immune regulation | ATAD1, CABIN1, DGLUCY, FYB1, GMIP, ICE2, KMT5B, NLRC3 +4 more |
About the gene
| Synonyms | MGC20369, NFX2, TEG-42, Tex42 |
|---|---|
| Chromosome | 9: 33290512-33371157 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor, Transferase |
| Biological process | Host-virus interaction, Transcription, Transcription regulation, Ubl conjugation pathway |
Function
Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X- box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.