Immune Negative Regulation
Gene co-expression module in Gamma-delta T cells
| Category | Immune regulation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
CABIN1 is a calcineurin-binding protein that suppresses NFAT-driven T cell activation. NLRC3 is an NLR family member that negatively regulates NF-κB and PI3K-mTOR signaling in immune cells. FYB1 (ADAP) is a T cell signaling scaffold involved in integrin activation and TCR signaling. NUMB inhibits Notch signaling and regulates cell fate. NFX1 is a transcriptional repressor. Together these genes suggest a program of negative immune regulation and T cell signaling attenuation. Moderate coherence reflects the mixed regulatory mechanisms involved.
Genes
ATAD1, CABIN1, DGLUCY, FYB1, GMIP, ICE2, KMT5B, NFX1, NLRC3, NOL8, NUMB, PHKB, POC1B
Most correlated modules
- Interferon Antiviral Response · correlation 0.84
- Actin Cytoskeletal Regulation · correlation 0.84
- Chromatin TF Regulation · correlation 0.81
- mTOR-Exocyst Signaling · correlation 0.80
- Metabolic-Translational Coupling · correlation 0.80
- Ubiquitin Protein Quality · correlation 0.78
- Interferon Stimulated Genes · correlation 0.77
- Rho GTPase Signaling · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.