FYB1 — FYN binding protein 1

FYB1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

FYB1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Post-transcriptional regulation RNA processing	BCL11B, CCDC14, CHD2, CHD6, CREBZF, DDX39B, DNASE1, EVI2B +21 more	View in SCUBA
Gamma-delta T cells	Immune Negative Regulation Immune regulation	ATAD1, CABIN1, DGLUCY, GMIP, ICE2, KMT5B, NFX1, NLRC3 +4 more
Innate lymphoid cells	NK Homing Circulating Homing & TEM	ADD3, ANXA1, APOBEC3G, C16orf54, C1orf162, CAPG, CASP4, CAST +37 more	View in SCUBA
Macrophages	Endosomal Membrane Trafficking Vesicular traficking	A2M, AP1B1, ARHGAP4, ARHGEF6, ATG4C, B3GNT7, CRTAP, ETV5 +20 more	View in SCUBA
Monocytes	Inflammatory Monocyte Activation Inflammatory	AQP9, BACH1, CCR1, DAPP1, DUSP6, IFI16, JAK2	View in SCUBA
Natural Killer cells	NK Homeostatic Survival Immune regulation	ACAP1, ARHGAP30, CAPN12, GIMAP6, GPR174, IRF2, SLFN5, STOM +1 more	View in SCUBA

About the gene

Synonyms	ADAP, FYB, FYB-120/130, SLAP-130
Chromosome	5: 39105252-39274528
Predicted location	Intracellular
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Predicted intracellular proteins

Function

Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.