CABIN1 — Calcineurin binding protein 1
CABIN1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CABIN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Immune Negative Regulation Immune regulation | ATAD1, DGLUCY, FYB1, GMIP, ICE2, KMT5B, NFX1, NLRC3 +4 more | |
| Mucosal-associated invariant T cell | PI3K-Calcineurin Signaling TCR Signaling | ACLY, BCL9L, CDK11A, LATS2, NBPF19, NUP210, PIK3CD, POM121C +2 more |
About the gene
| Synonyms | KIAA0330, PPP3IN |
|---|---|
| Chromosome | 22: 24011192-24178628 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | Chromatin regulator |
Function
May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.