NOTCH2NLA — Notch 2 N-terminal like A
NOTCH2NLA belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NOTCH2NLA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Monocytes | Stress-Adapted Macrophage Stress | DDIT4, KAT2A, MS4A4E, SESN1, SIAH2, SIGLEC11, TCN2 | View in SCUBA |
About the gene
| Synonyms | N2N, NOTCH2NL |
|---|---|
| Chromosome | 1: 146146203-146229041 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Notch signaling pathway |
Function
Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2. Also promotes Notch signaling pathway in a cell- autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.