Stress-Adapted Macrophage
Gene co-expression module in Monocytes
| Category | Stress |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes SIAH2 (E3 ubiquitin ligase activated under hypoxia/oxidative stress, targets HIF-1alpha regulators), SESN1 (sestrin-1, p53-inducible stress sensor that inhibits mTORC1 and activates AMPK), DDIT4/REDD1 (stress-induced mTOR inhibitor, hypoxia/glucocorticoid target), KAT2A (GCN5 histone acetyltransferase involved in stress-responsive chromatin remodeling), and SIGLEC11 (inhibitory sialic acid-binding receptor on macrophages) together suggest a stress-adapted macrophage state with mTOR suppression. TCN2 (transcobalamin II) is expressed in monocytes. The module shows moderate expression and lower detection rate, consistent with a stress-induced subpopulation. Neighbor context with M99 (glucocorticoid/mTOR suppression) supports a stress/metabolic adaptation theme.
Genes
DDIT4, KAT2A, MS4A4E, NOTCH2NLA, SESN1, SIAH2, SIGLEC11, TCN2
Most correlated modules
- Monocyte Identity · correlation 0.77
- Tissue-Resident Macrophage · correlation 0.74
- IL-18 Inflammasome Response · correlation 0.72
- Efferocytosis Tissue Macrophage · correlation 0.72
- Glucocorticoid Response · correlation 0.69
- M2 Macrophage Polarization · correlation 0.66
- Inflammatory Monocyte Activation · correlation 0.62
- Complement C1q Macrophage · correlation 0.60
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.