SIAH2 — Siah E3 ubiquitin protein ligase 2
SIAH2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SIAH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Naive B-cell identity B cell maturation | ALOX5AP, CD79B, HLA-DOB, IRF8, NCF1, P2RX5, PLEKHF2, SEC62 +7 more | View in SCUBA |
| CD4⁺ T cells | Oxidative Phosphorylation Mitochondrial & OxPhos | ANP32B, ATP5MC2, C19orf53, COX7C, EIF3H, EIF3M, EMC7, GPX4 +10 more | View in SCUBA |
| Gamma-delta T cells | Stress Epigenetic Silencing DNA/chromatin regulation | ALKBH5, ANKHD1, EPC2, FAM53C, MXD1, NEU1, OTUD4, PHF1 +8 more | |
| Monocytes | Stress-Adapted Macrophage Stress | DDIT4, KAT2A, MS4A4E, NOTCH2NLA, SESN1, SIGLEC11, TCN2 | View in SCUBA |
| Mucosal-associated invariant T cell | mRNA Decay Program RNA processing & translation | ATP6V0C, BCL7B, BTG1, BTG3, CCDC59, DDIT4, DUSP2, DYNLL2 +13 more |
About the gene
| Chromosome | 3: 150741125-150763477 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters |
| Molecular function | Transferase |
| Biological process | Apoptosis, Biological rhythms, Cell cycle, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA. Regulates cellular clock function via ubiquitination of the circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation. Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance. Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin- mediated proteasomal degradation of AXIN1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.