PAK1IP1 — PAK1 interacting protein 1
PAK1IP1 belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PAK1IP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Ribosome Biogenesis RNA processing & translation | ABCE1, BRIX1, BUD23, C12orf57, CDK4, DCAF13, DDX21, DKC1 +30 more | View in SCUBA |
About the gene
| Synonyms | bA421M1.5, FLJ20624, hPIP1, MAK11, PIP1, WDR84 |
|---|---|
| Chromosome | 6: 10694972-10709782 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Signal transduction inhibitor |
| Biological process | Ribosome biogenesis |
Function
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.