Ribosome Biogenesis
Gene co-expression module in Colonocytes
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 19 of 39 genes have a known function matching the annotation |
Why this annotation
Hub genes NOLC1, DKC1 (dyskerin, pseudouridylation of rRNA), FBL (fibrillarin, rRNA methylation), WDR43, GPATCH4, MRTO4, DDX21 (nucleolar RNA helicase), NOP58 (box C/D snoRNP), BUD23 (rRNA methyltransferase), RRP15, BRIX1 are all canonical nucleolar ribosome biogenesis factors. IMPDH2 provides GTP for rRNA synthesis. ABCE1 is a ribosome recycling factor. CDK4 drives ribosome biogenesis transcriptionally. PAICS is involved in purine biosynthesis supporting nucleotide pools. HNRNPD and HNRNPA1 are RNA-binding proteins involved in pre-rRNA processing. This is a tightly coherent ribosome biogenesis module enriched in proliferating crypt colonocytes, suppressed in UC inflammation.
Genes
Most correlated modules
- SWI-SNF DNA Repair · correlation 0.96
- SUMOylation Chromatin · correlation 0.96
- snRNP Splicing · correlation 0.95
- eIF3 Translation Initiation · correlation 0.95
- Ribosome Biogenesis · correlation 0.94
- DNA Repair Housekeeping · correlation 0.94
- Chaperone Proteostasis · correlation 0.92
- Mitochondrial Translation · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.