CDK4 — Cyclin dependent kinase 4
CDK4 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDK4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | RNA Processing RNA processing | ANP32A, CCDC167, CENPX, CYC1, FDPS, GGCT, LSM3, LSM4 +14 more | View in SCUBA |
| Endothelial | Nuclear Transport Housekeeping | AAMDC, ANP32B, CBX5, CKAP4, COMMD4, COQ2, CSE1L, DAZAP1 +18 more | View in SCUBA |
| Gamma-delta T cells | Cell Cycle Entry Cell cycle | DCTPP1, FH, GGCT, GSS, ISOC2, MBD3, MTHFD1, NABP2 +4 more | |
| Hematopoietic progenitor cells | RNA Processing Housekeeping Housekeeping | ATP5MC1, C1QBP, DUT, FABP5, HSPE1, LSM5, NDUFAF8, NME1 +8 more | |
| Innate lymphoid cells | ILC1 Effector Activation activation | ADAM19, ARHGEF3, BATF, CD151, FES, FURIN, HLA-F, IL22 +16 more | View in SCUBA |
| Macrophages | Replication Chromatin Assembly Cell cycle | ANP32B, CBX3, COPS3, DEK, DNMT1, EMC8, EXOSC8, FDPS +22 more | View in SCUBA |
About the gene
| Synonyms | PSK-J3 |
|---|---|
| Chromosome | 12: 57747727-57756013 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Essential proteins, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Cell cycle, Cell division |
Function
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.