BUD23 — BUD23 rRNA methyltransferase and ribosome maturation factor
BUD23 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
BUD23's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB activation TCR/AP1/NFKb pathway | ABCF1, BCL2A1, BZW2, CALR, CEBPZ, DDX21, DENND4A, GNL3 +21 more | View in SCUBA |
| Gamma-delta T cells | RNA Processing RNA processing & translation | ATP5F1A, ATP5F1B, ATP5F1C, ATP5IF1, CIAO2B, E2F4, ELAVL1, FAM50A +12 more | |
| Innate lymphoid cells | RNA Chromatin Regulation RNA processing & translation | ACADM, AURKAIP1, CBX3, CMC2, COPB1, DNAJA2, DYNC1LI1, G3BP1 +19 more | View in SCUBA |
| Macrophages | Protein Biogenesis Housekeeping | ATP6V0D1, B3GAT3, C11orf58, CHD4, CNPY2, DAZAP1, DDX46, DNAJA2 +23 more | View in SCUBA |
About the gene
| Synonyms | MERM1, MGC19709, MGC2022, MGC5140, PP3381, WBMT, WBSCR22 |
|---|---|
| Chromosome | 7: 73683597-73698212 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Methyltransferase, Transferase |
| Biological process | Ribosome biogenesis, rRNA processing, Transcription, Transcription regulation |
Function
S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(7) position of a guanine in 18S rRNA. Requires the methyltransferase adapter protein TRM112 for full rRNA methyltransferase activity. Involved in the pre-rRNA processing steps leading to small-subunit rRNA production independently of its RNA-modifying catalytic activity. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2), although direct histone methyltransferase activity is not observed in vitro.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.