PMF1 — Polyamine modulated factor 1
PMF1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PMF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | RNA processing splicing RNA processing | BUD31, DNAJC8, EDF1, EIF2S1, GTF3C6, HPRT1, ILF2, LAMTOR5 +11 more | View in SCUBA |
| Gamma-delta T cells | snRNP Splicing RNA processing & translation | CHCHD2, DAZAP1, GAPDH, GIT1, GUK1, HDGF, ILF2, LAMTOR5 +16 more |
About the gene
| Chromosome | 1: 156212993-156240042 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Activator |
| Biological process | Cell cycle, Cell division, Chromosome partition, Mitosis, Transcription, Transcription regulation |
Function
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. May act as a cotranscription partner of NFE2L2 involved in regulation of polyamine-induced transcription of SSAT.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.