snRNP Splicing
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 25 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 25 genes have a known function matching the annotation |
Why this annotation
Top hub genes SNRPB, SNRPD1, SNRPA1, SNRPC are core spliceosomal snRNP proteins, with DAZAP1, ILF2 as RNA-binding/splicing regulators. Proteasome components PSMD7, PSMB1, POMP and mitochondrial genes (UQCRFS1, NDUFA6, CHCHD2, MRPS7, SLC25A3) co-express due to shared housekeeping co-regulation. Spliceosome genes dominate by PageRank. Uniform expression confirms housekeeping program.
Genes
CHCHD2, DAZAP1, GAPDH, GIT1, GUK1, HDGF, ILF2, LAMTOR5, MRPS15, MRPS7, NDUFA6, NDUFS5, PMF1, POMP, PSMB1, PSMD7, RNF145, SLC25A3, SNRPA1, SNRPB, SNRPC, SNRPD1, SUMO3, UQCRFS1, VDAC2
Most correlated modules
- Mitochondrial ETC · correlation 0.88
- Proteasome Complex · correlation 0.81
- G1/S Entry · correlation 0.80
- Electron Transport Chain · correlation 0.80
- RNA Binding/Splicing · correlation 0.78
- Anabolic Activation Response · correlation 0.77
- ER Protein Biogenesis · correlation 0.76
- RNA Processing · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.