PPIL2 — Peptidylprolyl isomerase like 2
PPIL2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPIL2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Macrophage Endocytic Signaling Lysosomal & pahgocytosis | APLP2, ARHGAP30, ARHGEF2, ATF6B, BAG6, CLSTN1, CMTR2, CTBS +20 more | View in SCUBA |
About the gene
| Synonyms | CYC4, Cyp-60, UBOX7 |
|---|---|
| Chromosome | 22: 21666000-21700015 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | mRNA processing, mRNA splicing, Ubl conjugation pathway |
Function
Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'- linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl- prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.