Macrophage Endocytic Signaling
Gene co-expression module in Macrophages
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 29 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 29 genes have a known function matching the annotation |
Why this annotation
Hub genes include PPM1B (PP2C phosphatase, stress signaling), TMEM127 (mTOR regulator), ARHGAP30 (Rho GTPase-activating protein), LRP1 (low-density lipoprotein receptor-related protein, major macrophage endocytic receptor), VAMP2 (vesicle-associated membrane protein, SNARE), ARHGEF2 (Rho GEF), DSE (dermatan sulfate epimerase, ECM), TPST2 (tyrosine sulfotransferase, Golgi), APLP2 (amyloid precursor-like, membrane), CTBS (di-N-acetylchitobiase, lysosomal), ATF6B (ER stress TF). LRP1 is a canonical macrophage endocytic/phagocytic receptor. VAMP2, CTBS, and SERINC1 suggest vesicular/lysosomal activity. ARHGAP30/ARHGEF2 indicate Rho signaling. The module is mixed but LRP1-centered endocytosis and Rho-mediated cytoskeletal regulation in macrophages is the strongest theme.
Genes
APLP2, ARHGAP30, ARHGEF2, ATF6B, BAG6, CLSTN1, CMTR2, CTBS, DSE, EIF4EBP2, HNRNPH2, LRP1, MSL1, OSBPL11, PLEKHO2, PPIL2, PPM1B, PPP1R3B, PTAFR, RESF1, SERINC1, SLC35E1, TMEM127, TMEM170A, TOPORS, TPST2, VAMP2, YIPF4, ZBED5
Most correlated modules
- ER Membrane Homeostasis · correlation 0.96
- Autophagy Vesicular Trafficking · correlation 0.95
- Ubiquitin-ERAD Proteostasis · correlation 0.94
- Autophagy Lysosomal Regulation · correlation 0.94
- Pre-mRNA Splicing · correlation 0.94
- Golgi-Endosome Trafficking · correlation 0.94
- General Cellular Maintenance · correlation 0.94
- RNA Splicing Processing · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.