ATF6B — Activating transcription factor 6 beta
ATF6B belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ATF6B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Glycosylation & trafficking Protein processing & ER | AASDHPPT, ABHD12, ACTR1A, ANKRD35, AP1S1, ARRDC1, ATG5, CDK19 +25 more | View in SCUBA |
| Gamma-delta T cells | ER-Lysosomal Trafficking Protein processing & ER | ARL6IP5, BORCS6, CD53, CLN3, DHRS7, MGAT1, MMP23B, NAA40 +12 more | |
| Innate lymphoid cells | Mitochondrial Metabolic Housekeeping Mitochondrial & OxPhos | ALKBH7, BCAS1, COQ8A, DDT, DNAJC4, DPM3, EIF3M, FDFT1 +16 more | View in SCUBA |
| Macrophages | Macrophage Endocytic Signaling Lysosomal & pahgocytosis | APLP2, ARHGAP30, ARHGEF2, BAG6, CLSTN1, CMTR2, CTBS, DSE +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Endosomal Actin Organization Cytoskeletal | ARHGEF2, CGGBP1, FUT11, IARS2, ICE2, INPP5B, SH3BP2, SMC1A +7 more |
About the gene
| Synonyms | CREBL1, G13 |
|---|---|
| Chromosome | 6: 32115264-32128253 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted membrane proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation, Unfolded protein response |
Function
Precursor of the transcription factor form (Processed cyclic AMP- dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane. Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR). Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.