PPP1R1A — Protein phosphatase 1 regulatory inhibitor subunit 1A
PPP1R1A belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PPP1R1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Smooth muscle cells | Muscle Energy Metabolism Mitochondrial & OxPhos | ANP32B, HACD1, HEY2, MAP3K20, MRPS6, PIP5K1B, PNRC2, PRPSAP1 +4 more | View in SCUBA |
About the gene
| Chromosome | 12: 54575387-54588659 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Protein phosphatase inhibitor |
| Biological process | Carbohydrate metabolism, Glycogen metabolism |
Function
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.