Muscle Energy Metabolism
Gene co-expression module in Smooth muscle cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
The module mixes muscle energy/calcium-handling genes (SLC25A4/ANT1 adenine nucleotide translocase, PPP1R1A protein phosphatase-1 inhibitor-1 downstream of PKA in Ca2+ handling, HACD1 muscle-specific very-long-chain fatty-acid dehydratase, MRPS6 mitoribosome) with amino-acid/nucleotide supply (SLC38A1, PRPSAP1) and a few regulatory genes (MAP3K20/ZAK muscle stress kinase, HEY2 Notch effector, REEP1, TERF1, ANP32B). The unifying theme is metabolic/energetic support of the differentiated myocyte, echoing the OxPhos content of neighbor M109; heterogeneity of the peripheral genes lowers confidence.
Genes
ANP32B, HACD1, HEY2, MAP3K20, MRPS6, PIP5K1B, PNRC2, PPP1R1A, PRPSAP1, REEP1, SLC25A4, SLC38A1, TERF1
Most correlated modules
- Actomyosin Regulation · correlation 0.83
- Myogenic Cytoskeletal Program · correlation 0.80
- Vascular SMC Identity · correlation 0.76
- Wnt-Notch Modulation · correlation 0.72
- Oxidative Muscle Metabolism · correlation 0.72
- FOXC-PRDM16 Program · correlation 0.67
- Pericyte Signature · correlation 0.61
- Adrenergic Neuronal Transcripts · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.