PIP5K1B — Phosphatidylinositol-4-phosphate 5-kinase type 1 beta

PIP5K1B belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PIP5K1B's module in each cell type

Cell type	Module	Shares the module with
Enterocytes	YAP cytoskeletal remodeling Migration & adhesion	ABLIM1, AHCYL2, ARHGAP26, CCSER1, CDC42BPA, FGD4, ITGB8, PDE4D +5 more	View in SCUBA
Smooth muscle cells	Muscle Energy Metabolism Mitochondrial & OxPhos	ANP32B, HACD1, HEY2, MAP3K20, MRPS6, PNRC2, PPP1R1A, PRPSAP1 +4 more	View in SCUBA

About the gene

Synonyms	MSS4, STM7
Chromosome	9: 68705240-69009176
Predicted location	Intracellular
Essential gene	No
Protein class	Enzymes, Metabolic proteins, Predicted intracellular proteins
Molecular function	Kinase, Transferase
Biological process	Lipid metabolism

Function

Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion (By similarity)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.