HACD1 — 3-hydroxyacyl-CoA dehydratase 1
HACD1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HACD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Activated Treg Immune regulation | ACOT9, AHSP, AKIP1, BASP1, CASP1, CCR8, CD177, CSF2RB +13 more | View in SCUBA |
| Fibroblasts | ICC contractility Gut motility | BEX1, BTC, DES, HSPB7, IL17B, KCNMA1, LDB3, MTSS1 +7 more | View in SCUBA |
| Hematopoietic progenitor cells | Erythro-Megakaryocytic Development Erythropoietic | CAMLG, ICAM4, IL1B, LYL1, MPP1, NFE2, NT5M, PLEK +1 more | |
| Smooth muscle cells | Muscle Energy Metabolism Mitochondrial & OxPhos | ANP32B, HEY2, MAP3K20, MRPS6, PIP5K1B, PNRC2, PPP1R1A, PRPSAP1 +4 more | View in SCUBA |
About the gene
| Synonyms | CAP, PTPLA |
|---|---|
| Chromosome | 10: 17589032-17617374 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein, Lyase |
| Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Function
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum- bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. In tooth development, may play a role in the recruitment and the differentiation of cells that contribute to cementum formation. May also bind hydroxyapatite and regulate its crystal nucleation to form cementum
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.