Smooth muscle cells: gene co-expression modules
Contractile mesenchymal cells forming the gut wall muscularis layers; rich in actin-myosin filaments, they drive peristaltic contraction, regulate motility, and modulate stromal and inflammatory signalling.
SCUBA's reference network for Smooth muscle cells holds 124 gene modules covering 1,528 genes. Each module is a group of genes that rise and fall together across these cells, annotated with the biological process it most likely represents.
View the Smooth muscle cells network in SCUBA
Activation (6)
- Activated Myofibroblast · 12 genes
- BMP/TGF-beta response · 10 genes
- Fibroblast-like Activation · 8 genes
- KLF6/ZNF24 regulators · 8 genes
- Mesenchymal lncRNA Activation · 11 genes
- STAT3 transcriptional program · 11 genes
Cell contamination (1)
- Telocyte/Fibroblast Contamination · 14 genes
Cell cycle (2)
- Anaphase Cytokinesis · 8 genes
- Mitotic Spindle · 13 genes
Contractility (17)
- Actomyosin Regulation · 15 genes
- Adrenergic Neuronal Transcripts · 11 genes
- Calcium Handling · 12 genes
- Calcium Handling Contractile · 8 genes
- Contractile SMC Identity · 9 genes
- Contractile SMC phenotype · 10 genes
- Contractile Tone Regulation · 11 genes
- Myogenic Cytoskeletal Program · 12 genes
- NO-cGMP Signaling · 11 genes
- Pericyte Vasoregulatory Identity · 15 genes
- SMC contractile apparatus · 11 genes
- SMC Contractile Apparatus · 12 genes
- SMC Contractile Signaling · 8 genes
- SMC Ion Signaling · 21 genes
- Vascular SMC Identity · 19 genes
- Vascular Tone Signaling · 14 genes
- Vasoconstrictor Signaling · 13 genes
Cytoskeletal (7)
- Actin Cytoskeletal Scaffold · 22 genes
- Actin remodeling · 8 genes
- Costameric cytoskeleton · 13 genes
- Cytoskeletal Scaffolding · 17 genes
- Cytoskeletal trafficking kinases · 15 genes
- Microtubule biogenesis · 12 genes
- Non-muscle Actomyosin · 13 genes
Development (17)
- Arteriolar Mural Cells · 12 genes
- BMP-antagonist Niche · 13 genes
- BMP-ID3 Matricellular · 8 genes
- Capillary Pericyte · 19 genes
- FOXC-PRDM16 Program · 13 genes
- FOXF2 Mesenchymal Patterning · 11 genes
- HOX Positional Identity · 19 genes
- Mural/Pericyte Identity · 15 genes
- Netrin Guidance Signaling · 8 genes
- Neural Adhesion Program · 10 genes
- Notch-TGFbeta Signaling · 12 genes
- Notch-TGFbeta Signaling · 12 genes
- Pericyte Notch Identity · 11 genes
- Pericyte Signature · 17 genes
- SMC Phenotype Regulation · 14 genes
- Wnt-Hedgehog Niche · 17 genes
- Wnt-Notch Modulation · 10 genes
DNA/chromatin regulation (1)
- Histone Variant Chromatin · 15 genes
ECM remodeling (14)
- Basement Membrane Matrix · 9 genes
- Collagen Biosynthesis · 13 genes
- Collagen-Laminin Deposition · 13 genes
- Fibroblast Matrisome · 10 genes
- Matrisome Regulators · 10 genes
- Matrix Crosslinking Activation · 8 genes
- Matrix-integrin interaction · 8 genes
- Microfibril ECM Assembly · 11 genes
- Microfibrillar ECM Program · 11 genes
- Pericellular Proteolysis · 9 genes
- Pericyte Basement Membrane · 16 genes
- Synthetic Matrix Phenotype · 10 genes
- TGFB-Collagen Remodeling · 8 genes
- Vascular Matrix Secretion · 8 genes
Housekeeping (19)
- Actin Dynamics Housekeeping · 12 genes
- Basal Maintenance Genes · 12 genes
- Basal metabolic housekeeping · 9 genes
- Basal Metabolic Housekeeping · 15 genes
- Baseline Maintenance Transcripts · 14 genes
- Endolysosomal Trafficking · 9 genes
- Generic maintenance transcripts · 14 genes
- Lipid Kinase Signaling · 19 genes
- Membrane Protein Turnover · 10 genes
- Mitochondrial Housekeeping · 11 genes
- OxPhos & Translation · 12 genes
- Post-translational regulators · 15 genes
- Proliferative Biosynthesis · 16 genes
- Redox-Metabolic Housekeeping · 8 genes
- Rho GTPase Housekeeping · 8 genes
- Sparse Mitoribosomal Housekeeping · 15 genes
- Translation elongation housekeeping · 13 genes
- Translocon & Proteostasis · 11 genes
- Ubiquitous Housekeeping Transcripts · 12 genes
Inflammation (4)
- IFN-gamma/NF-kB Response · 20 genes
- MHC-I antigen presentation · 11 genes
- Stromal Chemokine Secretion · 18 genes
- Type I Interferon · 12 genes
Migration & adhesion (4)
- Adhesion Activation · 12 genes
- Integrin adhesion complex · 12 genes
- Mesenchymal Adhesion Program · 15 genes
- SMC focal adhesion · 16 genes
Mitochondrial & OxPhos (6)
- ATP Synthase Complex · 17 genes
- Muscle Energy Metabolism · 13 genes
- Oxidative Muscle Metabolism · 11 genes
- OxPhos & proteasome · 17 genes
- OXPHOS Complex I · 12 genes
- Respiratory Chain Subunits · 11 genes
Protein processing & ER (8)
- ER Chaperone/UPR · 12 genes
- ER Secretory Trafficking · 9 genes
- ER-Golgi Secretory · 9 genes
- ER-Golgi Secretory Pathway · 13 genes
- Lysosomal Glycoprotein Catabolism · 9 genes
- Lysosomal-secretory processing · 14 genes
- Proteasome And Translation · 11 genes
- XBP1 UPR Response · 14 genes
RNA processing & translation (4)
- hnRNP & Proteasome · 11 genes
- mRNA Splicing Factors · 16 genes
- Ribonucleoprotein & translation · 14 genes
- Translation initiation/RNA-binding · 11 genes
Stress (13)
- Atrophy Proteolysis Program · 8 genes
- BAG3-HSPB8 proteostasis · 14 genes
- Chaperonin heat-shock · 9 genes
- Glucocorticoid Metallothionein Response · 12 genes
- Growth Arrest Stress · 8 genes
- Heat Shock Response · 17 genes
- Hypoxia-NRF2 Activation · 9 genes
- Immediate Early Response · 13 genes
- Immediate Early Response · 16 genes
- Mechanostress Early Response · 13 genes
- NF-kB Stress Response · 10 genes
- NR4A-ADAMTS Activation · 14 genes
- Secondary Response Genes · 12 genes
Technical artifact (1)
- Ambient High-Expressors · 11 genes