PTGES2 — Prostaglandin E synthase 2
PTGES2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTGES2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Mitochondrial Ribosome Mitochondrial & OxPhos | APEX1, APRT, EIF3M, EXOSC5, FAM162A, LSM7, MRPL24, MZT2A +10 more |
About the gene
| Synonyms | C9orf15, FLJ14038 |
|---|---|
| Chromosome | 9: 128120693-128128462 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Isomerase |
| Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism |
Function
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro). The biological function and the GSH- dependent property of PTGES2 is still under debate. In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy- 5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.