SCUBA

APRT — Adenine phosphoribosyltransferase

APRT belongs to a gene co-expression module in 10 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

APRT's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsImmunoproteasome IFN
Anti-viral
BATF, MT1X, MT2A, NIT2, PSMB9, PSME1, PSME2, VAMP5View in SCUBA
CD4⁺ T cellsRibosome biogenesis
Housekeeping
APEX1, C1QBP, CCDC59, HNRNPA1, IMPDH2, LBH, LDHA, LSM5 +17 moreView in SCUBA
FibroblastsRho GTPase Cytoskeletal
Cytoskeletal
CLIC1, CYBA, HSBP1, LY6E, RAB34, RHOA, RHOC, S100A11 +2 moreView in SCUBA
Gamma-delta T cellsMitochondrial Ribosome
Mitochondrial & OxPhos
APEX1, EIF3M, EXOSC5, FAM162A, LSM7, MRPL24, MZT2A, NHP2 +10 more
Goblet cellsNucleotide Metabolism Stress
Stress
CEBPD, CYB5A, LY6E, NFKBIZ, NME3, PNKD, TYMPView in SCUBA
Innate lymphoid cellsActin Cytoskeleton Remodeling
Cytoskeleton & motility
ARPC2, ARPC3, ATP5F1E, ATP6V0E1, C11orf58, CFL1, CHCHD2, COX6C +17 moreView in SCUBA
Lymphatic endothelialOxidative Stress Response
Stress
AP2S1, ATOX1, C4orf3, FKBP1A, GADD45GIP1, GSTP1, RABAC1, SH3BGRL3 +1 moreView in SCUBA
MacrophagesMitochondrial OXPHOS
Mitochondrial & OxPhos
ARPC3, ATP5F1E, ATP5MF, ATP5MG, BLOC1S1, BTF3, CLTB, COX4I1 +28 moreView in SCUBA
Mucosal-associated invariant T cellLeukocyte Housekeeping
Housekeeping
AP2S1, ATP5MC2, CCDC85B, EIF3G, ERP29, GABARAPL2, GMFG, HCST +5 more
Natural Killer cellsCellular Homeostasis
Metabolism
ATP5F1E, ATP6V0E1, CD63, DYNLRB1, OAZ1, PSMA7, SSR4, TMSB4X +1 moreView in SCUBA

About the gene

Chromosome16: 88809339-88811937
Predicted locationIntracellular
Essential geneNo
Protein classDisease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins
Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Function

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.