MZT2A — Mitotic spindle organizing protein 2A
MZT2A belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MZT2A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Leukocyte adhesion signaling migration & adhesion | ARHGDIB, BIN1, CD37, DGKA, DGKZ, EIF3F, EIF3L, EIF4B +22 more | View in SCUBA |
| Endothelial | Nuclear Transport Housekeeping | AAMDC, ANP32B, CBX5, CDK4, CKAP4, COMMD4, COQ2, CSE1L +18 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Ribosome Mitochondrial & OxPhos | APEX1, APRT, EIF3M, EXOSC5, FAM162A, LSM7, MRPL24, NHP2 +10 more | |
| Macrophages | Mitotic Spindle Assembly Cell cycle | ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX +34 more | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Surface Signaling TCR Signaling | CD37, ICAM3, LIME1, MFNG, NAA10, PLSCR3, SIGIRR | |
| Natural Killer cells | Glycolytic Metabolism Metabolism | COX5A, ENO1, GAPDH, MZT2B, PARP1, PRKDC, SET, SNRPB +2 more | View in SCUBA |
About the gene
| Synonyms | FAM128A, MOZART2A |
|---|---|
| Chromosome | 2: 131464900-131492743 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
Required for the recruitment and the assembly of the gamma- tubulin ring complex (gTuRC) at the centrosome. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.