LSM7 — LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
LSM7 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LSM7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | COX6B1, COX6C, COX7A2, COX7B, DBI, ELOB, NDUFB2, POMP +5 more | View in SCUBA |
| Endothelial | Endothelial NO Activation Endothelial cell development | BCL6B, BLOC1S1, CD99, CDH13, COX5A, CREM, DDAH2, DDX46 +8 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Ribosome Mitochondrial & OxPhos | APEX1, APRT, EIF3M, EXOSC5, FAM162A, MRPL24, MZT2A, NHP2 +10 more | |
| Goblet cells | Mitochondrial Biogenesis Mitochondrial & OxPhos | ARPC5L, CALM1, EIF5A, MRPL17, MRPL20, MRPL41, PFN1, PRELID1 +4 more | View in SCUBA |
| Hematopoietic progenitor cells | Metabolic Housekeeping Housekeeping | CRYGD, EBPL, HINT1, HSPB1, PCBD1, PPA1, TALDO1, YBX3 | |
| Innate lymphoid cells | Transcription RNA Processing RNA processing & translation | ARMCX6, BANF1, CCAR1, CLDND1, COMMD1, FEZ2, HELZ, HSBP1 +11 more | View in SCUBA |
| Macrophages | Mitochondrial Biogenesis Mitochondrial & OxPhos | AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1 +38 more | View in SCUBA |
About the gene
| Synonyms | YNL147W |
|---|---|
| Chromosome | 19: 2321520-2328611 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Ribonucleoprotein, RNA-binding |
| Biological process | mRNA processing, mRNA splicing |
Function
Plays a role in pre-mRNA splicing as component of the U4/U6- U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.