Mitochondrial Ribosome
Gene co-expression module in Gamma-delta T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes are strongly mitochondrial: OCIAD2 (OxPhos supercomplex assembly, inner mitochondrial membrane), TMEM14B (mitochondrial inner membrane), MRPL24 (mitochondrial ribosome large subunit), PHB2 (prohibitin 2, mitochondrial membrane scaffold and OxPhos complex stabilizer), SMDT1 (MICOS complex essential membrane protein), FAM162A (mitochondrial protein promoting apoptosis/hypoxia response), NME3 (nucleoside diphosphate kinase 3, mitochondrial). NHP2 (H/ACA snoRNP), EXOSC5 (exosome), LSM7 (RNA splicing), EIF3M (translation) are RNA/translation components. APRT (adenine salvage), PEBP1 (signaling), PTGES2 (prostaglandin synthase) are additional. The mitochondrial inner membrane and ribosome/assembly program is dominant, supported by the neighborhood context.
Genes
APEX1, APRT, EIF3M, EXOSC5, FAM162A, LSM7, MRPL24, MZT2A, NHP2, NME3, OCIAD2, PEBP1, PHB2, PTGES2, SMDT1, SPNS3, TMEM14B, TRAPPC6A, ZNF862
Most correlated modules
- Mitochondrial Dynamics · correlation 0.85
- Mitochondrial Housekeeping · correlation 0.83
- Translation Initiation · correlation 0.80
- Metabolic Housekeeping · correlation 0.79
- Electron Transport Chain · correlation 0.77
- Mitochondrial Translation · correlation 0.74
- ATP Synthase Complex · correlation 0.71
- RNA Splicing Nuclear · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.