PTPRF — Protein tyrosine phosphatase receptor type F
PTPRF belongs to a gene co-expression module in 1 of 30 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTPRF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Colonocytes | Nuclear Receptor Signaling Nutrient processing | APLP2, CCNDBP1, CYB5B, EIF4EBP2, ERBB3, HSD17B11, KIAA2013, MGAT4A +9 more | View in SCUBA |
About the gene
| Synonyms | LAR |
|---|---|
| Chromosome | 1: 43525187-43623666 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Heparin-binding, Hydrolase, Protein phosphatase, Receptor |
| Biological process | Cell adhesion |
Function
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.