RGS12 — Regulator of G protein signaling 12
RGS12 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RGS12's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Stress Response Transcription Stress | AHR, C11orf96, CBX6, FAM110A, FN3K, GADD45A, LACC1, LPAR6 +8 more | View in SCUBA |
About the gene
| Chromosome | 4: 3293021-3439913 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
| Molecular function | GTPase activation, Repressor, Signal transduction inhibitor |
| Biological process | Transcription |
Function
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP- bound form. Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.